Some Common Problems in Male Infertility
Azoospermia is defined as the absence/reduced no of sperms in the ejaculate. It has been considered as the most challenging issue associated with male infertility treatment. Azoospermia can be classified in three categories: pre-testicular (related to endocrine diseases), testicular (abnormal testis, atrophic or absent) and post-testicular (failure in ejaculation such as obstruction in reproductive ducts). Non-obstructive azoospermia is caused by testis failure in producing sperm.
Incidence: The prevalence of azoospermia is approximately 1% among all men and ranges between 10% and 15% among infertile men.
Erectile dysfunction is mainly characterized by the inability to develop or maintain an erection of the penis for a longer span, which can ultimately lead to Impotence. Although not life-threatening by itself, ED is a strong predictor of high mortality diseases such as coronary artery diseases and cardiovascular diseases.
Incidence: The global prevalence of ED can vary from 3 to 75%. Generally, 5% percent men in their 40s and about 15% men in their 70s suffer from erectile dysfunction.
Oligospermia is a male infertility issue characterized by a low sperm count. As per WHO classification, a sperm count below 15 million sperms/ml is considered critical and can be diagnosed as oligospermia. Nevertheless, in many cases, other aspects of male sexual health remain atypical, including the ability to gain erection.
Incidence: In several studies, the prevalence of oligospermia in males has been recorded around 15%.
Treatment of Infertility with Regenerative Cells: Regenerative Medicine Protocol
The diagnosis of male infertility will be established on the basis of two semen analysis evaluations done at separate occasions; this will be followed by detailed history taking, physical examination and investigations. Investigations include include testicular biopsy or transrectal ultrasound if indicated. Regenerative cell therapy for male infertility using multipotent regenerative cells is considered as the best treatment for male infertility without any risk/side effects. Regenerative cell therapy can be used for treatment of male infertility to repair inability and dysfunction of germ cells and also differentiation/ proliferation of germ cells. During spermatogenesis, different testicular cells -including germ, Sertoli, Leydig and peritubular myoid cells-interact with each other. Therefore, infusion into the testicular region is considered as an appropriate microenvironment to induce derivation of germ cells from different potent tissue sources of our bodies.